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1

Design and Synthesis of Macrocyclic Inhibitors of Phosphatase Cdc25B.

Stefan Baeurle, Thorsten Blume, Judith Guenther, Daniela Henschel, Roman C. Hillig, Manfred Husemann, Anne Mengel, Christian Parchmann, Elke Schmid, Werner Skuballa

Journal:

Year:

2004

Language:

english

File:

PDF, 128 KB

english, 2004

2

Design and synthesis of macrocyclic inhibitors of phosphatase Cdc25B

Stefan Bäurle, Thorsten Blume, Judith Günther, Daniela Henschel, Roman C. Hillig, Manfred Husemann, Anne Mengel, Christian Parchmann, Elke Schmid, Werner Skuballa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

3

Identifying protein construct variants with increased crystallization propensity––A case study

Guido A. Malawski, Roman C. Hillig, Felipe Monteclaro, Uwe Eberspaecher, Arndt A.P. Schmitz, Kerstin Crusius, Martina Huber, Ursula Egner, Peter Donner, Beate Müller-Tiemann

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 695 KB

english, 2006

4

Structural and Biochemical Properties Show ARL3-GDP as a Distinct GTP Binding Protein

Roman C. Hillig, Michael Hanzal-Bayer, Marco Linari, Jörg Becker, Alfred Wittinghofer, Louis Renault

Journal:

Year:

2000

Language:

english

File:

PDF, 426 KB

english, 2000

5

High-resolution structure of HLA-A∗0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene

Roman C Hillig, Pierre G Coulie, Vincent Stroobant, Wolfram Saenger, Andreas Ziegler, Martin Hülsmeyer

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 448 KB

english, 2001

6

Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase MK2

Roman C. Hillig, Uwe Eberspaecher, Felipe Monteclaro, Martina Huber, Duy Nguyen, Anne Mengel, Beate Muller-Tiemann, Ursula Egner

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 598 KB

english, 2007

7

Erratum to “Structural Basis for a High Affinity Inhibitor Bound to Protein Kinase MK2” [J. Mol. Biol. 369 (2007) 735–745]

Roman C. Hillig, Uwe Eberspaecher, Felipe Monteclaro, Martina Huber, Duy Nguyen, Anne Mengel, Beate Muller-Tiemann, Ursula Egner

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 233 KB

english, 2007

8

Fab MOR03268 Triggers Absorption Shift of a Diagnostic Dye via Packaging in a Solvent-shielded Fab Dimer Interface

Roman C. Hillig, Stefanie Urlinger, Jörg Fanghänel, Bodo Brocks, Cornelia Haenel, Yvonne Stark, Detlev Sülzle, Dmitri I. Svergun, Siegfried Baesler, Guido Malawski, Dieter Moosmayer, Andreas Menrad, M

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.72 MB

english, 2008

9

The Crystal Structure of rna1p: A New Fold for a GTPase-Activating Protein

Roman C. Hillig, Louis Renault, Ingrid R. Vetter, Theodore Drell IV, Alfred Wittinghofer, Jörg Becker

Journal:

Year:

1999

Language:

english

File:

PDF, 489 KB

english, 1999

10

Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories

Hartung, Ingo V., Hitchcock, Marion, Pühler, Florian, Neuhaus, Roland, Scholz, Arne, Hammer, Stefanie, Petersen, Kirstin, Siemeister, Gerhard, Brittain, Dominic, Hillig, Roman C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.56 MB

english, 2013

11

A structural biology view of target drugability

Egner, Ursula, Hillig, Roman C

Journal:

Expert Opinion on Drug Discovery

Year:

2008

Language:

english

File:

PDF, 965 KB

english, 2008

12

Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties

Hartung, Ingo V., Hammer, Stefanie, Hitchcock, Marion, Neuhaus, Roland, Scholz, Arne, Siemeister, Gerhard, Bohlmann, Rolf, Hillig, Roman C., Pühler, Florian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.89 MB

english, 2016

13

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2

Eggert, Erik, Hillig, Roman C., Köhr, Silke, Stöckigt, Detlef, Weiske, Jörg, Barak, Naomi, Mowat, Jeffrey, Brumby, Thomas, Christ, Clara D., ter Laak, Antonius, Lang, Tina, Fernández-Montalván, Amaury

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.90 MB

english, 2016

14

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

Kapoor, Khyati, Finer-Moore, Janet S., Pedersen, Bjørn P., Caboni, Laura, Waight, Andrew, Hillig, Roman C., Bringmann, Peter, Heisler, Iring, Müller, Thomas, Siebeneicher, Holger, Stroud, Robert M.

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.56 MB

english, 2016

15

Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles

Hartung, Ingo V., Pühler, Florian, Neuhaus, Roland, Scholz, Arne, Siemeister, Gerhard, Geisler, Jens, Hillig, Roman C., von Ahsen, Oliver, Hitchcock, Marion

Journal:

Year:

2015

Language:

english

File:

PDF, 1.71 MB

english, 2015

16

Back Cover: Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles (ChemMedChem 12/2015)

Hartung, Ingo V., Pühler, Florian, Neuhaus, Roland, Scholz, Arne, Siemeister, Gerhard, Geisler, Jens, Hillig, Roman C., von Ahsen, Oliver, Hitchcock, Marion

Journal:

Year:

2015

File:

PDF, 2.84 MB

2015

17

[ACM Press the 2018 CHI Conference - Montreal QC, Canada (2018.04.21-2018.04.26)] Proceedings of the 2018 CHI Conference on Human Factors in Computing Systems - CHI '18 - AdaM

Park, Seonwook, Oulasvirta, Antti, Hilliges, Otmar, Gebhardt, Christoph, Rädle, Roman, Feit, Anna Maria, Vrzakova, Hana, Dayama, Niraj Ramesh, Yeo, Hui-Shyong, Klokmose, Clemens N., Quigley, Aaron

Year:

2018

Language:

english

File:

PDF, 4.59 MB

english, 2018

18

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmann, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, J

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.86 MB

2019

19

Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure- guided Amelioration of its CYP3A4 Induction Profile

Werner, Stefan, Mesch, Stefanie, Hillig, Roman Christian, ter Laak, Antonius M., Klint, Julie, Neagoe, Ioana, Laux-Biehlmann, Alexis, Dahllöf, Henrik, Braeuer, Nico, Puetter, Vera, Nubbemeyer, Reinhar

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 926 KB

english, 2019

20

Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure- guided Amelioration of its CYP3A4 Induction Profile

Werner, Stefan, Mesch, Stefanie, Hillig, Roman Christian, ter Laak, Antonius M., Klint, Julie, Neagoe, Ioana, Laux-Biehlmann, Alexis, Dahllöf, Henrik, Braeuer, Nico, Puetter, Vera, Nubbemeyer, Reinhar

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 926 KB

2019

21

Discovery of BAY-985 a highly selective TBK1/Ikkε inhibitor

Lefranc, Julien, Schulze, Volker K., Hillig, Roman Christian, Briem, Hans, Prinz, Florian, Mengel, Anne, Heinrich, Tobias, Bálint, József, Rengachari, Srinivasan, Irlbacher, Horst, Stöckigt, Detlef, B

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 1.05 MB

2019

22

Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C

Mortier, JÃ©rÃ©mie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut

Journal:

Year:

2020

File:

PDF, 1.29 MB

2020

23

Front Cover: Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS G12C (ChemMedChem 10/2020)

Mortier, JÃ©rÃ©mie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut

Journal:

Year:

2020

File:

PDF, 999 KB

2020

24

Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics

Hillisch, Alexander, Gericke, Kersten M., Allerheiligen, Swen, Roehrig, Susanne, Schaefer, Martina, Tersteegen, Adrian, Schulz, Simone, Lienau, Philip, Gnoth, Mark, Puetter, Vera, Hillig, Roman C., He

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 7.22 MB

2020